Gerben Vader

Work

Princess Máxima Center

Netherlands

Apr 2024→ Present

Cancer Center Amsterdam/Amsterdam UMC

Principal investigator/Researcher

Netherlands

Jan 2020→ Mar 2024

Max-Planck-Institut für molekulare Physiologie

Junior Group Leader

Germany

Oct 2012→ Sep 2020

Whitehead Institute for Biomedical Research

Mar 2008→ Jan 2012

Education

University Medical Centre Utrecht

Netherlands

Mar 2008→ Jan 2012

PhD

Netherlands Cancer Institute

Netherlands

Mar 2008→ Jan 2012

PhD

Wageningen University and Research Centre

Netherlands

Mar 2008→ Jan 2012

MSc

University of Applied Sciences

Netherlands

Mar 2008→ Jan 2012

BSc

Publications

Cancer and meiotic gene expression: Two sides of the same coin?

Current Topics in Developmental Biology

Jan 2023

book-chapter

Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics

Current Topics in Developmental Biology

Jan 2023

book-chapter

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complex

Jan 2022

preprint

Studying meiosis in mitosis: Activating the meiosis-specific Red1-Hop1-Mek1 complex in mitotic budding yeast cells

bioRxiv

Jan 2022

preprint

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

eLife

Jan 2021

journal-article

Getting there: understanding the chromosomal recruitment of the AAA+ ATPase Pch2/TRIP13 during meiosis

Current Genetics

Jan 2021

journal-article

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

Jan 2020

preprint

Active transcription and Orc1 drive chromatin association of the AAA+ ATPase Pch2 during meiotic G2/prophase

PLOS Genetics

Jan 2020

journal-article

A dCas9/CRISPR-based targeting system identifies a central role for Ctf19 in kinetochore-derived suppression of meiotic recombination

Jan 2020

preprint

Homeostatic control of meiotic G2/prophase checkpoint function by Pch2 and Hop1

Jan 2020

preprint

ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes.

Life science alliance

Jan 2020

journal-article

Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly

Life Science Alliance

Jan 2020

journal-article

Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1

Current Biology

Jan 2020

journal-article

A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination

Genetics

Jan 2020

journal-article

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

bioRxiv

Jan 2020

preprint

Kinetochores, cohesin, and DNA breaks: Controlling meiotic recombination within pericentromeres

Yeast

Jan 2019

journal-article

Kinetochores, cohesin, and DNA breaks: Controlling meiotic recombination within pericentromeres

Yeast

Jan 2019

journal-article

Kinetochores, cohesin, and DNA breaks: Controlling meiotic recombination within pericentromeres

Yeast

Jan 2019

journal-article

Kinetochores, cohesin, and DNA breaks: Controlling meiotic recombination within pericentromeres

Yeast

Jan 2019

journal-article

The greatest kinetochore show on earth

EMBO Reports

Jan 2017

journal-article

The greatest kinetochore show on earth.

EMBO reports

Jan 2017

journal-article

The greatest kinetochore show on earth

EMBO reports

Jan 2017

journal-article

The greatest kinetochore show on earth

EMBO Reports

Jan 2017

journal-article

The greatest kinetochore show on earth

EMBO Reports

Jan 2017

journal-article

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair

PLoS Biology

Jan 2016

journal-article

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair.

Jan 2016

journal-article

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair

PLoS Biology

Jan 2016

journal-article

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair

PLoS Biology

Jan 2016

journal-article

The kinetochore prevents centromere-proximal crossover recombination during meiosis

eLife

Jan 2015

journal-article

Pch2(TRIP13): controlling cell division through regulation of HORMA domains.

Jan 2015

journal-article

Pch2^TRIP13: controlling cell division through regulation of HORMA domains

Chromosoma

Jan 2015

journal-article

Pch2^TRIP13: controlling cell division through regulation of HORMA domains

Chromosoma

Jan 2015

journal-article

Pch2^TRIP13: controlling cell division through regulation of HORMA domains

Chromosoma

Jan 2015

journal-article

The kinetochore prevents centromere-proximal crossover recombination during meiosis.

Jan 2015

journal-article

The kinetochore prevents centromere-proximal crossover recombination during meiosis

eLife

Jan 2015

journal-article

The kinetochore prevents centromere-proximal crossover recombination during meiosis

eLife

Jan 2015

journal-article

HORMA domains at the heart of meiotic chromosome dynamics

Developmental Cell

Jan 2014

journal-article

HORMA domains at the heart of meiotic chromosome dynamics.

Jan 2014

journal-article

HORMA domains at the heart of meiotic chromosome dynamics

Developmental Cell

Jan 2014

journal-article

HORMA domains at the heart of meiotic chromosome dynamics

Developmental Cell

Jan 2014

journal-article

Protection of repetitive DNA borders from self-induced meiotic instability

Nature

Jan 2011

journal-article

Protection of repetitive DNA borders from self-induced meiotic instability.

Jan 2011

journal-article

Protection of repetitive DNA borders from self-induced meiotic instability

Nature

Jan 2011

journal-article

Protection of repetitive DNA borders from self-induced meiotic instability

Nature

Jan 2011

journal-article

Chromosome segregation: Taking the passenger seat

Current Biology

Jan 2010

journal-article

Chromosome segregation: taking the passenger seat.

Jan 2010

journal-article

Chromosome segregation: Taking the passenger seat

Current Biology

Jan 2010

journal-article

Chromosome segregation: Taking the passenger seat

Current Biology

Jan 2010

journal-article

Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates.

Jan 2009

journal-article

Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates

Science

Jan 2009

journal-article

Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates

Science

Jan 2009

journal-article

Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates

Science

Jan 2009

journal-article

Global analysis of the meiotic crossover landscape.

Jan 2008

journal-article

Global Analysis of the Meiotic Crossover Landscape

Developmental Cell

Jan 2008

journal-article

Global Analysis of the Meiotic Crossover Landscape

Developmental Cell

Jan 2008

journal-article

Global Analysis of the Meiotic Crossover Landscape

Developmental Cell

Jan 2008

journal-article

The Aurora kinase family in cell division and cancer.

Jan 2008

journal-article

The Aurora kinase family in cell division and cancer

Biochimica et Biophysica Acta - Reviews on Cancer

Jan 2008

journal-article

The Aurora kinase family in cell division and cancer

Biochimica et Biophysica Acta - Reviews on Cancer

Jan 2008

journal-article

The Aurora kinase family in cell division and cancer

Biochimica et Biophysica Acta - Reviews on Cancer

Jan 2008

journal-article

The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond.

Jan 2008

journal-article

The chromosomal passenger complex and the spindle assembly checkpoint: Kinetochore-microtubule error correction and beyond

Cell Division

Jan 2008

journal-article

The chromosomal passenger complex and the spindle assembly checkpoint: Kinetochore-microtubule error correction and beyond

Cell Division

Jan 2008

journal-article

The chromosomal passenger complex and the spindle assembly checkpoint: Kinetochore-microtubule error correction and beyond

Cell Division

Jan 2008

journal-article

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions.

Jan 2007

journal-article

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule-kinetochore interactions

Molecular Biology of the Cell

Jan 2007

journal-article

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule-kinetochore interactions

Molecular Biology of the Cell

Jan 2007

journal-article

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule-kinetochore interactions

Molecular Biology of the Cell

Jan 2007

journal-article

The case for Survivin as mitotic regulator

Current Opinion in Cell Biology

Jan 2006

journal-article

The case for Survivin as mitotic regulator

Current Opinion in Cell Biology

Jan 2006

journal-article

The case for Survivin as mitotic regulator

Current Opinion in Cell Biology

Jan 2006

journal-article

Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown.

Jan 2006

journal-article

Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown

Oncogene

Jan 2006

journal-article

Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown

Oncogene

Jan 2006

journal-article

Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown

Oncogene

Jan 2006

journal-article

The chromosomal passenger complex: guiding Aurora-B through mitosis.

Jan 2006

journal-article

The chromosomal passenger complex: Guiding Aurora-B through mitosis

Journal of Cell Biology

Jan 2006

journal-article

The chromosomal passenger complex: Guiding Aurora-B through mitosis

Journal of Cell Biology

Jan 2006

journal-article

The chromosomal passenger complex: Guiding Aurora-B through mitosis

Journal of Cell Biology

Jan 2006

journal-article

Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.

Jan 2006

journal-article

Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres

Molecular Biology of the Cell

Jan 2006

journal-article

Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres

Molecular Biology of the Cell

Jan 2006

journal-article

Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres

Molecular Biology of the Cell

Jan 2006

journal-article

Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.

Jan 2006

journal-article

Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody

EMBO Reports

Jan 2006

journal-article

Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody

EMBO Reports

Jan 2006

journal-article

Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody

EMBO Reports

Jan 2006

journal-article

The case for Survivin as mitotic regulator.

Jan 2006

journal-article

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis.

Jan 2004

journal-article

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

Journal of Biological Chemistry

Jan 2004

journal-article

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

Journal of Biological Chemistry

Jan 2004

journal-article

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

Journal of Biological Chemistry

Jan 2004

journal-article

Gerben Vader

Work

Princess Máxima Center

Cancer Center Amsterdam/Amsterdam UMC

Max-Planck-Institut für molekulare Physiologie

Whitehead Institute for Biomedical Research

Education

University Medical Centre Utrecht

Netherlands Cancer Institute

Wageningen University and Research Centre

University of Applied Sciences

Publications

Cancer and meiotic gene expression: Two sides of the same coin?

Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complex

Studying meiosis in mitosis: Activating the meiosis-specific Red1-Hop1-Mek1 complex in mitotic budding yeast cells

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

Getting there: understanding the chromosomal recruitment of the AAA+ ATPase Pch2/TRIP13 during meiosis

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

Active transcription and Orc1 drive chromatin association of the AAA+ ATPase Pch2 during meiotic G2/prophase

A dCas9/CRISPR-based targeting system identifies a central role for Ctf19 in kinetochore-derived suppression of meiotic recombination

Homeostatic control of meiotic G2/prophase checkpoint function by Pch2 and Hop1

ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes.

Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly

Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1

A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

Kinetochores, cohesin, and DNA breaks: Controlling meiotic recombination within pericentromeres

Kinetochores, cohesin, and DNA breaks: Controlling meiotic recombination within pericentromeres

Kinetochores, cohesin, and DNA breaks: Controlling meiotic recombination within pericentromeres

Kinetochores, cohesin, and DNA breaks: Controlling meiotic recombination within pericentromeres

The greatest kinetochore show on earth

The greatest kinetochore show on earth.

The greatest kinetochore show on earth

The greatest kinetochore show on earth

The greatest kinetochore show on earth

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair.

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair

Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair

The kinetochore prevents centromere-proximal crossover recombination during meiosis

Pch2(TRIP13): controlling cell division through regulation of HORMA domains.

Pch2TRIP13: controlling cell division through regulation of HORMA domains

Pch2TRIP13: controlling cell division through regulation of HORMA domains

Pch2TRIP13: controlling cell division through regulation of HORMA domains

The kinetochore prevents centromere-proximal crossover recombination during meiosis.

The kinetochore prevents centromere-proximal crossover recombination during meiosis

The kinetochore prevents centromere-proximal crossover recombination during meiosis

HORMA domains at the heart of meiotic chromosome dynamics

HORMA domains at the heart of meiotic chromosome dynamics.

HORMA domains at the heart of meiotic chromosome dynamics

HORMA domains at the heart of meiotic chromosome dynamics

Protection of repetitive DNA borders from self-induced meiotic instability

Protection of repetitive DNA borders from self-induced meiotic instability.

Protection of repetitive DNA borders from self-induced meiotic instability

Protection of repetitive DNA borders from self-induced meiotic instability

Chromosome segregation: Taking the passenger seat

Chromosome segregation: taking the passenger seat.

Chromosome segregation: Taking the passenger seat

Chromosome segregation: Taking the passenger seat

Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates.

Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates

Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates

Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates

Global analysis of the meiotic crossover landscape.

Global Analysis of the Meiotic Crossover Landscape

Global Analysis of the Meiotic Crossover Landscape

Global Analysis of the Meiotic Crossover Landscape

The Aurora kinase family in cell division and cancer.

The Aurora kinase family in cell division and cancer

The Aurora kinase family in cell division and cancer

The Aurora kinase family in cell division and cancer

The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond.

The chromosomal passenger complex and the spindle assembly checkpoint: Kinetochore-microtubule error correction and beyond

The chromosomal passenger complex and the spindle assembly checkpoint: Kinetochore-microtubule error correction and beyond

The chromosomal passenger complex and the spindle assembly checkpoint: Kinetochore-microtubule error correction and beyond

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions.

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule-kinetochore interactions

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule-kinetochore interactions

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule-kinetochore interactions

Pch2^TRIP13: controlling cell division through regulation of HORMA domains

Pch2^TRIP13: controlling cell division through regulation of HORMA domains

Pch2^TRIP13: controlling cell division through regulation of HORMA domains